at present, China’s bran has more than 40 million patients with urine, . an increasing number of diabetics has been or is about to use insulin therapy. Using insulin therapy include patients with type ⅰ diabetes mellitus in patients with diabetes, they do not make insulin are prone to ketoacidosis and life-threatening.
in addition, patients with diabetes mellitus complicated pregnancy, generally advocate while preparing the pregnant women should start insulin, diabetes for maximum control, and the next health baby safe.
someone abroad, said “the proportion of patients with type ⅱ diabetes mellitus insulin a country that reflects the level of treatment of diabetes in this country. This phrase, “have a point. Insulin therapy can bring great benefits to patients, mainly to the patient’s condition is getting the best control, its sugar, protein, fat, water, salt and acid-base metabolism balance maintained to prevent or delay the emergence and development of acute and chronic complications of diabetes mellitus, allow patients to maintain good physical and mental state, maintaining a normal life and work.
first, early insulin therapy, blood glucose control with satisfaction, on islet cells are the best protection. Secondly, insulin therapy is a minimum impact on the liver, kidneys, stomach, intestine diabetes treatments, meaning it’s side effects are minimal. Third, with oral hypoglycemic drug prices soar, insulin treatment for relatively low cost. Some told the doctors that patients with insulin, they very nervous before playing insulin, fear, actual playing with insulin didn’t feel so terrible, but feel good about yourself. Therefore, patients do not resist the insulin, so as to avoid failure condition.
do not use injected insulin
up to now, injected insulin is one of the best treatments for patients with diabetes, insulin requires repeated injections, after all, if a person shot 3 times a day a total injection of 30, that means injection of more than 30,000 has helped this cumbersome, inconvenience and pain are normal people cannot understand. So, people do not need injection of insulin preparations have great expectations of domestic and foreign experts have invested a lot of time and financial commitment to this work, and considerable progress has been made. Now, progress has been made on the study of non-injecting insulin delivery methods include:
1, insulin eye drops: dropping insulin preparations in crumpled sheets, be absorbed through the conjunctiva, animal experiments had been successful, are now at the stage of clinical trials. Clinical study on the insulin preparations and observation. Insulin eye drops that may exist in such a problem is that the organs of the eye is a sophisticated, long term infusion of insulin eye drops will cause eye, especially corneal injury, this issue has yet to be studied.
2 and insulin-like nasal drops: play a role through the nasal mucosa absorption, has certain effect, but may cause nasal mucosal edema, resulting in stuffy. Danger of nasal mucosa atrophy caused by long-term use there.
3, insulin spray: respiratory tract after the small bronchial alveolar mucosa absorption or inhalation, corroborated by animal experiments, and has a good effect. When you use more convenient, spray nozzle in the mouth, deep breaths while the spray, inhaled insulin trachea, due to the small bronchi and alveoli is very large, its surface and not undermine the substance of insulin, so this method easy, has been on the market of such products.
4, oral insulin preparations: this is the most interesting non-injection administration of insulin. As a result of the package of ways to protect insulin preparations, oral insulin in stomach and small intestine is not compromised, decomposition, in the large intestine released and absorbed through the intestinal mucosa. This research was further improved in animal experiments. Facing a big difficulty is, how to make the changes of blood glucose and insulin absorption speed synchronization. By
5, skin penetration: insulin preparations on the skin surface, with the help of ion active substances penetration makes insulin the body, such an approach is also under study.
although not inject insulin administration are not mature enough, but it has many advantages, suffering in patients with very small, and is very promising. Non-insulin Administration will eventually replace the insulin injection therapy in the near future.